What do you know about hyaluronic acid?
Hyaluronic acid is a key substance used in cosmetics. However, its potential is much greater - it can also be effective as a dietary supplement or a medical product. Learn about the indications in which it shows therapeutic effects.
HYALURONIC ACID - REGENERATION FROM SKIN TO JOINTS
THE PROPERTIES OF HYALURONIC ACID DEPEND ON MOLECULAR WEIGHT!
AS A POLYMER (GLYCOSAMINOGLYCAN), THIS SUBSTANCE CAN HAVE A HIGH MOLECULAR WEIGHT (high molecular weight hyaluronic acid, HMW HA ≥ 10^6 Da) AND THEN EXERT BENEFICIAL EFFECTS IN THE BODY.
LOW MOLECULAR WEIGHT FRACTIONS (LMW HA) MAY ACT DIFFERENTLY, E.G., PRO-INFLAMMATORY RATHER THAN ANTI-INFLAMMATORY. [3]
Hyaluronic acid is a naturally occurring component surrounding cells.
With age, there is a decrease in production and an increase in degradation of HMW HA, which contributes, among other things, to water loss from the skin, the formation of wrinkles, and the onset of symptoms of osteoarthritis. [3]
List of abbreviations used:
HA - hyaluronic acid
HMW - high molecular weight
LMW - low molecular weight
OVD - Ophthalmic Viscosurgical Device
References
1. Kang DY, Kim WS, Heo IS, Park YH, Lee S. Extraction of hyaluronic acid (HA) from rooster comb and characterization using flow field-flow fractionation (FlFFF) coupled with multiangle light scattering (MALS). J Sep Sci. 2010 Nov;33(22):3530-6.
2. Rangaswamy V, Jain D. An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus. Biotechnol Lett. 2008; 30:493–496.
3. Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic Acid in the Third Millennium. Polymers (Basel). 2018;10(7):701.
4. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253‐258.
5. Gold MH. Use of hyaluronic acid fillers for the treatment of the aging face. Clin Interv Aging. 2007;2(3):369‐376.
6. Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 2011 Sep;10(9):990-1000.
7. Poetschke J, Schwaiger H, Steckmeier S, Ruzicka T, Gauglitz GG. Anti-wrinkle creams with hyaluronic acid: how effective are they? MMW Fortschr Med. 2016 May 25;158 Suppl 4:1-6.
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